Countdown SfN: Alzheimer’s Disease

A few great events going on…
+ a quick review of current drugs

Alzheimer’s Disease Social:
Monday, Nov. 15, 6:45 – 8:45 p.m.

San Diego Marriott Hotel & Marina: Torrey 2 & 3 Chair: Rudolph E. Tanzi
Alzheimer Idol

Karaoke Night is back by popular demand. Come out for a night of entertainment and enjoyment. Belt out your favorite tunes and watch your colleagues embarrass themselves. Graduate students and postdocs are especially encouraged to participate. Organize your laboratory to present your favorite Alzheimer theme tunes. The names of the winners of the best performance competition will be forwarded to network television for further consideration.

Also, check out these related booths:

Alzheimer Drug Discovery Foundation (Booth# 3806)
Alzheimer Research Forum (Booth# 4010)
Alzheimer’s Association (Booth# 4126)

Drug Wrap-Up: Let’s have a quick review of the current treatments available for Alzheimer’s Disease.

Namenda® (memantine) by Forest Laboratories
It is an orally active N-methyl D-aspartate (NMDA) antagonist prescribed to treat symptoms of moderate to severe AD. Blocks the toxic effects associated with excess glutamate and regulates glutamate activation.

Razadyne® (galantamine) by Ortho-McNeil-Janssen Pharmaceuticals, Inc.
Cholinesterase inhibitor prescribed to treat symptoms of mild to moderate AD. Prevents the breakdown of acetylcholine and stimulates nicotinic receptors to release more acetylcholine in the brain.

Exelon® (rivastigmine) by Novartis
It is a reversible cholinesterase inhibitor prescribed to treat symptoms of mild to moderate AD. Prevents the breakdown of acetylcholine and butyryl- choline (a brain chemical similar to acetylcholine) in the brain. Now available in a patch.

Aricept® (donepezil) by Pfizer
Cholinesterase inhibitor prescribed to treat symptoms of mild to moderate, and moderate to severe AD. It is a reversible inhibitor of the acetylcholinesterase enzyme. Prevents the breakdown of acetylcholine in the brain.

Other therapies include:
Gamma Secretase Inhibitors, Tau Inhibitors, Immunotherapy and Monoclonal Antibodies

For a more comprehensive review of these therapies, including dosage and symptoms click here.

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